icon-angle affirmation icon-arrow Arrow left icon-bell Notifications icon-book icon-calendar icon-caret icon-chevron icon-check-circle Close icon-close icon-compound icon-crown icon-crown-alt icon-crown-mono icon-edit icon-email icon-facebook icon-featured-star icon-featured-star-colored icon-file icon-file-meditation icon-file-mp3 icon-file-pdf icon-folder icon-get-pdf Headphones icon-join icon-linkedin icon-live-video icon-lock icon-map-pin icon-masterClasses Meditation Navigation Menu icon-messages icon-mic icon-microClasses mp3 icon-music-note My List icon-oasis pdf person icon-play icon-play-circle icon-plusOne icon-pnotes Podcast qa-cta-icon icon-quote icon-quote-left icon-quote-right icon-reload Search Search icon-settings icon-skinny-arrow icon-star icon-star-filled icon-triangle-down icon-triangle-rounded icon-twitter icon-user icon-warning icon-website icon-youtube feature-affirmations feature-big-ideas feature-bonus-wrksheets feature-meditation feature-mp3-guides feature-mp3 feature-pdfs feature-pntv feature-posters feature-transformational feature-workbooks master-classes philosophers-notes feature-meditation feature-worksheet membership-icon-4@2x feature-watch feature-read feature-listen feature-connect
Sign Up arrow icon
Cancer as a Metabolic Disease - Journal Article Book Cover

Cancer as a Metabolic Disease - Journal Article Open Access Journal Article from Nutrition & Metabolism

Cancer as a Metabolic Disease - Journal Article

Open Access Journal Article from Nutrition & Metabolism

This is our fourth Note specifically related to cancer I created after my brother’s diagnosis. The Note is on an open access article from the scientific journal Nutrition and Metabolism that Nasha Winters says is a “must read!” (I agree! Super compelling.) Thomas Seyfried is the leading research scientist making the case for the metabolic approach to cancer (vs. as we’ve discussed, a genetic approach). He and Laura Shelton brilliantly and lucidly unpack the case for cancer as a metabolic disease. Bonus: Your brain gets a nice workout as every word is chosen wisely for peer-reviewable hardiness. Big Ideas we explore include the genes vs. metabolism discussion, why your mitochondria are so important, and the two key therapeutic responses if you believe the metabolic approach.

Get the Notes!

Get the Notes!

“Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.”

- Thomas Seyfried, Laura Shelton from Cancer as a Metabolic Disease - Journal Article
Related +1s
All +1s

Two Theories on the Origins of Cancer
#385
Get instant access to all +1's!

Join nearly 10,000 members in the
1,000-Day Epic Optimizing Challenge
and start optimizing your life today.

Genes vs. Metabolism <-- What’s the REAL Cause?

Get instant access to all +1's!

Join nearly 10,000 members in the
1,000-Day Epic Optimizing Challenge
and start optimizing your life today.

Get instant access to all +1's!

Join nearly 10,000 members in the
1,000-Day Epic Optimizing Challenge
and start optimizing your life today.

+1 inspired by Note: Cancer as a Metabolic Disease - Journal Article

#385
Get instant access to all +1's!

Join nearly 10,000 members in the
1,000-Day Epic Optimizing Challenge
and start optimizing your life today.

Get instant access to all +1's!

Join nearly 10,000 members in the
1,000-Day Epic Optimizing Challenge
and start optimizing your life today.

Get instant access to all +1's!

Join nearly 10,000 members in the
1,000-Day Epic Optimizing Challenge
and start optimizing your life today.